Pramoxine Topical

What is pramoxine topical?

Pramoxine topical (brand names: Comfort; Micro-Pearls Advantage Dermal-Soothe®; Pramox-1®; Relief®, others) is a topical anesthetic (numbing agent) used to reduce pain and itching temporarily in cats, dogs, and other animals. It is often part of a combination product with other medications.

Its use may be off label (extra label) depending on species and jurisdiction. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions very carefully, as their directions may be significantly different from those on the label.

How do I give my pet pramoxine topical?

Pramoxine topical comes in ointment, spray, rinse, shampoo, and mousse forms.

• All forms are applied topically directly to the skin. 
• Wash your hands before and after applying this medication or wear gloves.
• Follow product-specific label directions for use.
• Do not allow grooming, chewing, or licking of the application site for at least 30 minutes after applying this medication.
• Avoid contact with eyes.
• Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.

This medication will take effect shortly after application, though outward effects may not be immediately noticeable. 

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once.

Are there any potential side effects?

Pramoxine topical may cause the following side effects:

• Mild irritation or redness at application site

Serious adverse reactions may occur. If any of the following signs develop, stop giving pramoxine topical and contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours.

Are there any risk factors for this medication?

DO NOT USE pramoxine in:

• Animals who are allergic to any component

USE WITH CAUTION in:

• Animals who may require intradermal allergy testing (a two-week withdrawal period prior to testing is recommended)

Are there any drug interactions I should be aware of?

There are no documented drug interactions for pramoxine topical. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Your veterinarian will let you know when and how they want to reassess your pet to ensure the medication is working and not causing side effects. 
• At home, monitor for any abnormal changes. If any occur, discontinue the medication and contact your veterinarian.

How do I store pramoxine topical?

• Store at room temperature, do not freeze.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.